Low Testosterone Hormone Therapy

If you have fatigue, poor concentration and erectile dysfunction, Low T hormone therapy may help. Just don't call it the fountain of youth.

Want to pump up your sex drive and muscles, boost your mood and motivation, and have the concentration and energy levels of a college undergrad? It's true that for guys who have low testosterone (Low T) hormone therapy can help address symptoms such as fatigue and erectile dysfunction, but it's not the fountain of youth and it shouldn’t be treated as an elixir for men looking to reclaim the vigor of their school years. Declining testosterone levels are a normal part of aging and don't always warrant treatment.

Be Sure It's Really Low T

Are you tired, irritable, and/or disinterested in all the things that once brought you joy, including sex? If you suspect you have Low T, your doctor can order a blood test, but only after ruling out other causes, such as depression, says Robert Brannigan, a urologist at Northwestern Memorial Hospital and associate professor of urology at Northwestern University Feinberg School of Medicine. Many symptoms of Low T, such as fatigue and erectile dysfunction, mimic depression or present as a side effect of heart disease, obesity, or other health condition. It's important to figure out if an underlying medical condition, such as an autoimmune disorder, is causing your Low T.

Is Testosterone Hormone Therapy Right for You?

According to Brannigan, testosterone levels vary widely from one man to the next. Healthy men can have testosterone levels between 270 and 1,070 ng/dL. "There are very few absolute indications for treating low testosterone," he says.

In other words, treating is optional. In his practice, Brannigan follows the The Endocrine Society's recommendations: If a man doesn't have evidence of breast cancer or untreated prostate cancer; his testosterone levels are below 300; and he's bothered by symptoms of low testosterone, he's a candidate. While there's no doubt that treatment can improve the quality of life for men with low testosterone levels, there's no consensus on whether it's beneficial to men who aren't suffering from so-called "male menopause."

Benefits and Risks of Testosterone Hormone Therapy

Bringing testosterone levels back to normal can boost energy, muscle mass, bone density, and concentration. It can also help with erectile dysfunction. Hormone therapy may even alleviate symptoms of depression. But it's not without risks.

Testosterone hormone replacement therapy may encourage prostate growth and increase your risk of prostate cancer. Testosterone also lives up to its red-blooded reputation by driving red blood cell production. According to Brannigan, this can make the blood too thick and increase the risk for stroke. Other less-serious side effects include unwanted body hair, acne, breast enlargement, and fluid retention.

Low T Treatment Options

Several vehicles deliver the right amount of testosterone to replacement therapy patients:

    Injections, usually once every two to three weeks
    Daily patches worn on the body or scrotum
    Topical gels applied daily to the shoulders, arms, or abdomen

It takes at least eight weeks for testosterone therapy to take effect, and because there's no cure for Low T, men generally require ongoing treatment, Brannigan says. Because of the risks of testosterone therapy, you'll need to follow up with your doctor regularly.

How does training affect your sex life?

One of the key hormones in the body that affects both training and sex is testosterone, which just happens to be one of the main sexual hormones. Accordingly, it's not hard to see how these two factors would go hand in hand.
Your sex drive
The first thing to consider in this picture is your sex drive. Will training impact how frequently you want to have sex?

Let's take a closer look at the testosterone connection here:

It's no secret that a higher testosterone level in males increases their sex drive. When a man's testosterone level begins to fall as he ages or due to other health-related factors, the libido will usually start to diminish as well.

Sometimes, if the condition is severe enough, doctors may place certain men on testosterone replacement therapy to help bring their hormonal levels back up to normal. Once these levels have been increased again, libido should rise and the desire and sexual performance (sometimes low testosterone can contribute to erectile dysfunction) should improve as well.

It only stands to reason, then, that anything you can do to increase your natural testosterone production should serve to further enhance sex drive levels. This is where weight lifting comes in.

When a man participates in heavy weight training, the levels of testosterone in his body will shoot up — assuming, of course, that this program is appropriate. Do note that overtraining is one of the biggest killers of testosterone, so taking this point too far and doing a very large volume of weight lifting will actually work against you and your testosterone levels.

Getting on a proper program where you are doing 20-40 sets maximum per workout will help to ensure that you aren't going overboard. Additionally, be sure that when you are lifting, you are lifting heavy amounts. The weight is really the key here — just be sure you are still using proper form and not overdoing it.

Additionally, certain exercises will also affect your sex drive more than others will. To fully maximize testosterone, full squats are a must. These will use so many muscle fibers in the body that it would be hard not to get a good testosterone release because of them.

Aside from squats, all the other compound movement lifts will be your best allies when it comes to increasing your sex drive. These exercises include:

    Bench press
    Bent-over row
    Stiff-legged deadlift
    Lunges
    Shoulder press
    Back squat
    Pull-ups

Incorporating these movements into your workout routine would be highly beneficial to your sex drive.


Sex and strength
The next point in this scenario is how having sex will affect your strength and workout performance. Some guys are so intently focused on their training that they want to be sure that frequent sessions in the bedroom are not going to have a negative impact on their sessions in the gym.

Generally speaking, having frequent sex won't impact your weight-lifting performance. If anything, it should increase your workout performance since, once again, sex causes a release of the hormone testosterone, and the more testosterone one has circulating throughout the body, the more muscle tissue can be built.

Further examination of the connection between training and sex...
The one time it might come into play is if you have just finished having sex and then head straight to the gym. You may find your performance isn't as good, because for some men, sex can cause muscular fatigue; for others, though, it actually energizes them. This is solely dependent on the individual and his sexual aftermath.

The Effects of Testosterone on Libido

Sexual stimulation and erection begin in the brain when neuronal testosterone-receptor sites are prompted to ignite a cascade of biochemical events that involve testosterone-receptor sites in the nerves, blood vessels, and muscles. Free testosterone promotes sexual desire and then facilitates performance, sensation, and the ultimate degree of fulfillment.

Without adequate levels of free testosterone, the quality of a man's sex life is impacted and the genitals atrophy. When free testosterone is restored, positive changes in structure and function of the sex organs can be expected. (It should be noted that sexual dysfunction can be caused by other factors unrelated to hormone balance such as arteriosclerotic blockage of the penile arteries.)

The genital/pelvic region is packed with testosterone receptors that are ultra-sensitive to free testosterone-induced sexual stimulation. Clinical studies using testosterone injections, creams, or patches have often failed to provide a long-lasting libido enhancing effect in aging men. (98) We now know why. The testosterone can be converted to estrogen. The estrogen is then taken up by testosterone receptor sites in cells throughout the body. When an estrogen molecule occupies a testosterone receptor site on a cell membrane, this blocks the ability of serum testosterone to induce a healthy hormonal signal. It does not matter how much serum free testosterone is available if excess estrogen is competing for the same cellular receptor sites.

Estrogen can also increase the production of sex hormone-binding globulin (SHBG), which binds the active free testosterone into a non-active "bound testosterone". Bound testosterone is not able to be picked up by testosterone receptors on cell membranes. For testosterone to produce long-lasting libido enhancing effects, it must be kept in the "free" form (not bound to SHBG) in the bloodstream. It is also necessary to suppress excess estrogen as this hormone can compete for testosterone receptor sites in the sex-centers of the brain and the genitals.

Restoring youthful hormone balance can have a significant impact on male sexuality.

Anabolic Steroids and Infertility

Anabolic Steroids are synthetic substances similar to the male sex hormone testosterone. If used consistently from a young age they can be detrimental to the users health because they upset the body's hormonal balance.

Anabolic Steroids are known to have a variety of harmful side effects, are out of bounds for athletes and users are required to only take them under prescription of a medical doctor. Yet many people take them for the short term benefits they provide - for athletes to improve performance or to enhance physical appearance.

These drugs are often sold on the black market and because their short term benefits are so attractive users tend to ignore the dangerous and possible long term side effects. Users do not consider the effects these substances may have on their fertility health.
   

 Medical Benefits

Steroids aren't only used for bulking up but can be prescribed for legitimate medical reasons. Your medical practioner is well aware of the side effects and will prescribe a dosage with this in mind to cater for your particular situation.


 Some of the medical uses are:

    Men with too little testosterone - Whether it's due to an accident or a disease; such as testicular cancer, some men have to have their testicles removed.Their bodies will no longer be able to produce testosterone. They will be given prescribed oral anabolic steroids to replace the testosterone.

    People with chronic illnesses, such as cancer or even AIDS can use anabolic steroids to stimulate their appetite and help build muscle.
    Pituitary problems -  Steroids can help adolescent males with pituitary problems. When the pituitary gland malfunctions, the brain signals to the testes may not function correctly and the testes therefore does not produce testosterone. Boys suffering from this condition can be prescribed steroids at the appropriate age, as per his doctor. This treatment will allow them to develop secondary sexual characteristics, such as a deepening of the voice, growth spurts and pubic and facial hair.

Anabolic Steroids and fertility

There are a number of side effects users will experience when taking these substances. Some are short term and others may have long term side effects. Unfortunately any side effects will in most cases also effect the male fertility health. Some of these side effects can include:

Short term effects

    Puffiness and swelling in the face and neck due to increased water retention.
    Development of breast tissue in males.
    Increased risk of injury to muscles and joints.
    Increase in muscle mass.
    Heightened aggression, sleeping disorders, anxiety and irritability.
    Stunted growth if taken during adolescent growth spurts due to skeletal maturation and accelerated puberty changes.
    

Long term effects

    Growth of breasts due to the high level of testosterone some of which the body converts to oestrogen.
    Increased erectile dysfunction and shrinking testicles.
    Heart and liver disease - some steroids are toxic to the liver.
    Kidney disease due to the increase in toxins to be broken down.
    Aggressive behaviour and depression.
    Jaundice from high levels of steroids - affects liver function.
    Increased blood pressure.
    Prostate enlargement.


Anabolic Steroids and male infertility are often linked due to the effects on the body as mentioned here.  Any increased toxins in the body have the potential to affect the sperm being produced.

A semen analysis will give a good indication of the health of the sperm if a male has used steroids previously and is now having difficulty with infertility. A low sperm count will also be detected by going for a semen analysis.

Fortunately medical technology and advancement in procedures such as sperm washing as well as ICSI - Intra-Cytoplasmic Sperm Injection could assist men whose fertility may have been affected by the usage of Steroids.

Your doctor will be able to advise you on using an Assisted Reproductive Technology (ART) procedure in the event of being diagnosed with infertility due to this usage.

HMG: The Miracle Fertility Med?

When we administer certain hormones into our bodies, various cells and organs have the ability to sense this. Your body 'sees' this increase in testosterone or similar molecules and as a result it can sense that it is in a higher concentration than what would be normal in the blood. As a result, it will shut down its own testosterone production. There are various mechanisms involved in this, but an important one is the cessation in production of luteinizing hormone (LH) and follicle stimulating hormone (FSH), produced by the pituitary gland. These hormones are required for the testes to be stimulated to produce testosterone but also play a role in sperm production.

From a blood-testosterone aspect this all seems okay to us, sure we have shut down natural testosterone production, but we still have testosterone in us; right? Well, one of the big problems with regards to fertility is that the testes do not work like that. The Leydig cells in the testes produce testosterone when stimulated by LH. Testosterone is released from these cells which are in close proximity to the Sertoli cells. When Sertoli cells see a high concentration of testosterone, they are stimulated to produce and mature sperm by the process of spermatogenesis. A high blood concentration of testosterone will not do this job. Thus administering anabolic androgenic steroids (AAS) will shut down natural testosterone production which will in turn slow down (and eventually near turn off) the proper formation and maturation of sperm. Thus infertility is a serious issue with use of anabolic steroids.

Classically, HCG has been seen to rectify this problem in males. HCG is an LH analogue – it 'looks' like LH to the body and so it can stimulate the Leydig cells to produce testosterone and in turn, hopefully, restore fertility. In some cases this will occur, and many people have had success from HCG therapy relating to infertility. However, the response is not robust and certainly with longer shut-down periods, many often find the use of HCG (even in combination with other post cycle therapy (PCT) medicines such as clomifene (aka clomid) and tamoxifen (aka nolvadex), etc) to not be effective at restoring fertility.

Furthermore, what HCG lacks is to produce the important effects that FSH inflicts upon fertility. FSH, despite its name, is important in male fertility in two main pathways. The first thing it does is to enhance the action of LH, by increasing the amount of protein that will 'see' testosterone in the Sertoli cells. The more easily these cells can see testosterone, the more likely spermatogenesis will occur. Secondly, FSH enhances the maturation of sperm by effects on their primary division. These are two important aspects of the role of FSH in the male testes that HCG is not optimal in promoting.

HMG, or its full name Human Menopausal Gonadotropin, bears similarities to HCG in that while HCG is similar to human LH, HMG contains actual LH. Additionally (and crucially) though, HMG also contains purified FSH. The combination of these two hormones perform the effects described above: induction of natural testosterone production by Leydig cells, and subsequent formation and maturation of sperm cells. The result is improved and potentially recovered fertility for the male concerned.

Does HMG really work?
So often we hear about various different drugs and the science for them is sound, but real world evidence is lacking. There are a few studies performed on HMG over the last 25 years, and I would like to draw your attention to two of these studies, pointing out a few key details. The first goes back to 1985 by Ley & Leonard and is an important study as it looks at males who had previously encountered anabolic steroids treatment (treatment for low hormone levels including mainly testosterone). This study is available online and I encourage you to read it in more detail than the brief summary I will provide here.

They looked at 13 hypogonadotropic men all of who had undetectable levels of LH/FSH, lower than normal levels of testosterone and azoospermia, thus were unable to currently conceive. Obviously with the low hormonal levels there were issues with libido as well. Furthermore, there were instances where upon testis biopsies, Leydig cells were completely absent. Despite this, all 13 men responded to treatment with HCG with increasing testosterone levels. However, upon addition of HMG treatment, most men saw a further increase in testosterone, sometimes very large. HCG was able to increase sperm counts in most men slightly; however, only upon addition of HMG were sperm counts above 'normal' fertility levels (i.e. 20 million per ml) observed. The study indicates that the addition of HMG therapy surpasses any level that HCG treatment could achieve alone. Admittedly this is a particular subset of men who have medical conditions and abnormal hormone issues, but the results are interesting nonetheless.

The second is more recent by Buchter et al in 1998. This is even more interesting from the point of view that it looks at three times the number of cases as the previous study and in a different manner. Again, this study can be found online and I encourage you to read it. The most interesting result you could take away from this study is that in the group of men treated who suffered from hypopituitarism, all 21 treated with HCG/HMG achieved spermatogenesis and a large proportion (81%) was able to successfully achieve pregnancies. The discussion of this article is most interesting as it raises the points from its own study and the literature that many in the field believe that to achieve spermatogenesis and pregnancy in a gonadotropin-compromised individual requires combinational therapy of HCG and HMG. The important point to note is that HCG is not sufficient alone in many cases.

Given the fact that other studies point to HMG increasing endogenous testosterone further than HCG can, as those who have relatively 'normal' pituitaries but have compromised their function due to AAS use, it would be wise to consider the use of HMG. This would not only be for purposes of fertility, but to induce natural testosterone levels back to normal values when they have been suppressed. Treatment in this latest study was the use of HCG twice per week at 1000-2500IU per dose (Mon-Fri) and HMG three times per week at 75-150IU (Mon-Wed-Fri). Thus for bodybuilders seeking to regain fertility, spermatogenesis and restore natural testosterone levels but wishing to keep costs down, a weekly dose of the lower ends should be employed for at least one month.

A schedule would involve:
Monday: 1000-1500IU HCG + 75IU HMG
Wednesday: 75IU HMG
Friday: 1000-1500IU HCG + 75IU HMG

Depending on the amount of suppression this cycle may need to be lengthened for a further period.

Melanotan in Bodybuilding

To get a high quality bodybuilding competition tan athletes need to use the correct tanning products. The right color tan applied in the right way plays an important role between winning and losing a bodybuilding competition. A poor tan can seriously affect your chances of winning, whereas getting the very best ultimate tan can seriously improve your chances of success. So if you are serious about your On Stage Look then you should be very carefully while choosing method of tanning.

Now a beautiful and lasting tan may be obtained without UV exposure or fake tan. Tanning process in the body is the production of pigment in the skin cells called melanin. Melanin is produced by melanocytes, which are located in the basal layer of the epidermis. The stimulation of melanocytes to produce melanin is done by melanocortin hormone. Melanin absorbs harmful UV radiation, transforming them into harmless heat through a process called “ultrafast internal conversion.” By this process, the melanin can reduces the generation of free radicals to a minimum, and so prevents indirect DNA damage which can produce malignant skin melanomas.

Melanotan represent a hormone, analogue of melanocyte-stimulating (a-MSH) human hormone by which the body produces melanin that as we said earlier is protective pigment that protects the skin from harmful UV sun exposure. Melanotan hormone or simply said melanotan has additional properties – significantly increases the sex drive, reduces appetite, causing a persistent aversion to food, due to what can be achieved a powerful weight loss.

Melanotan was first synthesized at the University of Arizona. Researchers knew that the best way to protect skin against cancer is the activity of melanin in the cells, that is, the process of tanning. They suggested that the most effective way to protect skin against cancer will be stimulation of natural pigmentation system to produce a protective tan before exposure of skin to UV radiation.

In May 2010 the Italian Medicines Agency (AIFA – Agenzia Italiana del Farmaco) became the first national organization in the field of health, approving Melanotan as therapeutic agent for Italian citizens, reducing sensitivity to sunlight. In other countries it is widely used under the personal responsibility.
Melanotan is available both injectable stuff and nasal spray. (to see instruction please click here) After reaching the desired hue tanning frequency of use can be reduced.
Remember – the more you expose your skin to UV-radiation (solarium, sun) when taking Melanotan, the deeper and darker your tan will be (Melanotan stimulates human body to produce melanin, and thus, the skin darkens in response to UV-radiation instead of burning).
Then let’s make a summery, Melanotan apply:
- To obtain a stable effect of bright and beautiful tan without resorting to extended contact with sunlight or fake tan;
- In order to obtain improved contrast tan using additional exposure to the sun or solarium;
- In the case of interdiction to bronze or attend solarium, in order to protect against skin cancer and sunburn, especially in areas exposed to permanent effects of the sun;
- Melanotan is used to activate the sexual function and stabilizate libido;
- Also Melanotan is prescribed in cases of uncontrolled food intake, to significantly reduce appetite.
In some cases the usage of Melanotan can cause nausea, flushing of the face, decreased appetite, tiredness. Not everyone gets these side effects, but if it occurs it’s usually only after the first few dosages until the body adapts.

Anabolic Steroids and Muscles

Anabolic steroids, known technically as anabolic-androgen steroids or colloquially as "steroids" (or even "roids"), are drugs that mimic the effects of testosterone and dihydrotestosterone in the body. They increase protein synthesis within cells, which results in the buildup of cellular tissue (anabolism), especially in muscles. Anabolic steroids also have androgenic and masculinity-enhancing properties, including the development and maintenance of masculine characteristics such as the growth of the vocal cords, testicles and body hair (secondary sexual characteristics). Anabolic-androgenic steroids were first isolated, identified and synthesized in the 1930's, and are now used therapeutically in medicine to induce bone growth, stimulate appetite, induce male puberty and treat chronic wasting conditions, such as cancer and AIDS. Anabolic steroids also increase muscle mass and physical strength, and are therefore used by athletes and bodybuilders alike to enhance strength or physique. Known side effects include harmful changes in cholesterol levels (increased Low density lipoprotein and decreased High density lipoprotein), acne, high blood pressure and liver damage. Some of these effects can be mitigated by taking supplemental drugs.
Mechanism of action

The pharmacodynamics of anabolic steroids are unlike peptide hormones. Water-soluble peptide hormones cannot penetrate the fatty cell membrane, and only indirectly affect the nucleus of target cells through their interaction with the cell’s surface receptors. However, as fat-soluble hormones, anabolic steroids are membrane-permeable, and influence the nucleus of cells by direct action. The pharmacodynamic action of anabolic steroids begins when the exogenous hormone penetrates the membrane of the target cell and binds to an androgen receptor located in the cytoplasm of that cell. From there, the compound hormone-receptor diffuses into the nucleus, where it either alters the expression of genes or activates processes that send signals to other parts of the cell. Different types of anabolic steroids bind to the androgen receptor with different affinities, depending on their chemical structure. Some anabolic steroids such as methandrostenolone bind weakly to this receptor in vitro, but still exhibit androgenic effects in vivo. The reason for this discrepancy is not known. The effect of anabolic steroids on muscle mass is caused in at least two ways: first, they increase the production of proteins; second, they reduce recovery time by blocking the effects of the stress hormone cortisol on muscle tissue, so that catabolism of muscle is greatly reduced. Some hypothesize that this reduction in muscle breakdown may occur by way of anabolic steroids inhibiting the action of other steroid hormones called glucocorticoids, which promote the breakdown of muscles. Anabolic steroids also affect the number of cells that develop into fat-storage cells by instead favoring cellular differentiation into muscle cells. Additionally, anabolic steroids can decrease fat by increasing basal metabolic rate (BMR), since an increase in muscle mass increases BMR.
Physical effects

Anabolic steroids are testosterone and dihydrotestosterone hormone mimics that stimulate anabolism, specifically protein synthesis and muscle hypertrophy. Due to its similarity to the male sex hormones, using anabolic steroids can result in masculinization of women and changes to secondary sex characteristics of men. This makes steroids attractive to those wishing to alter their appearance, particularly for body building. Further negative side effects of anabolic steroids include stunted growth in adolescents, increase in cholesterol levels, high blood pressure, acne, liver damage and changes to the left ventricle of the heart, not to mention potential psychiatric issues. Despite these side effects, anabolic steroids can be used therapeutically to stimulate bone growth and appetite, and treat chronic wasting conditions associated with cancer and AIDS, though at much lower dosages than those used for performance enhancement.
Steroid abuse

Abuse of anabolic steroids differs from the abuse of other illicit substances, because the initial use of anabolic steroids is motivated not by the immediate euphoria that accompanies other abused drugs such as cocaine, heroin and marijuana, but by the user's desire to change their appearance and performance, characteristics of great importance to adolescents. These effects can boost confidence and strength, leading the user to overlook the potential serious long-term damage that these substances can cause. Due to the unfair advantage given to athletes and competitors who use anabolic steroids, all major sports associations have banned their use.

While anabolic steroids can enhance certain types of performance or appearance, they are dangerous drugs, and when used inappropriately, they can cause a host of severe, long-lasting and often irreversible negative health consequences. For example, they can stunt the height of growing adolescents, masculinize women and alter sex characteristics of men. Anabolic steroids can also lead to premature heart attacks, strokes, liver tumors, kidney failure and serious psychiatric problems. In addition, because steroids are often injected, users risk contracting or transmitting HIV or hepatitis.